Malignant forms of Mediterranean spotted fever: risk factors for fatal outcomes.

نویسندگان

  • Ivan Baltadzhiev
  • Nedialka Popivanova
  • Zaprian Zaprianov
چکیده

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Mediterranean spotted fever (MSF) or Boutonneuse fever is a tick-borne endemic disease caused by Rickettsia conorii. It is characterized by fever, maculo-papular rash and an eschar at the site of tick bite, named black spot or tache noire. MSF has usually mild or moderate course, and has long been considered a benign disease. However, very severe “malignant” forms have been observed with involv...

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5. Mumcuoglu KY, Keysary A, Gilead L. Mediterranean spotted fever in Israel: a tick-borne disease. Isr Med Assoc J. 2002;4:44–9. 6. De Sousa R, Ismail N, Dória-Nóbrega S, Costa P, Abreu T, França A, et al. The presence of eschars, but not greater severity, in Portuguese patients infected with Israeli spotted fever. Ann NY Acad Sci. 2005;1063:197–202. doi:10.1196/ annals.1355.032 7. Giammanco GM...

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Host- and microbe-related risk factors for and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients.

BACKGROUND The pathophysiologic mechanisms that determine the severity of Mediterranean spotted fever (MSF) and the host-related and microbe-related risk factors for a fatal outcome are incompletely understood. METHODS This prospective study used univariate and multivariate analyses to determine the risk factors for a fatal outcome for 140 patients with Rickettsia conorii infection admitted t...

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Spotted fevers, which are caused by Rickettsia spp. in the spotted fever group (SFG), have been recognized in people for more than a hundred years. The clinical signs are broadly similar in all of these diseases, but the course ranges from mild and self-limited to severe and life-threatening. For a long time, spotted fevers were thought to be caused by only a few organisms, including Rickettsia...

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عنوان ژورنال:
  • The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

دوره 20 5  شماره 

صفحات  -

تاریخ انتشار 2016